Detection of celiac disease in adult patients with type I diabetes mellitus … Original Research Article … |
The Egyptian Journal of Immunology E-ISSN (2090-2506) Volume 32 (3), July 2025 Pages: 01–09. www.Ejimmunology.org https://doi.org/10.55133/eji.320301 |
|
| Nagla M. B. El-Kholy1, Naglaa A. EL-Gendy1, Nessren M. B. Mohammed1, Hala E. Abd El Hamid2, Asmaa S. Hassan3, and Ayatalla R. Mohamed1 |
| 1Department of Hepatology, Gastroenterology & Infectious Diseases, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
2Department of Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. 3Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
|
Corresponding author: Ayatalla R. Mohamed, Department of Hepatology, Gastroenterology & Infectious Diseases, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. Email: Dr.aya_ragab@yahoo.com |
Abstract
Celiac disease (CD) is a chronic, immune-determined disorder that affects the small intestine in individuals with a genetic predisposition. Identifying silent CD is crucial, as a gluten-free diet in asymptomatic type 1 diabetes mellitus (T1DM) patients can improve glycemic control and growth. This study aimed to determine the prevalence of CD in adult T1DM patients by using serological immune-enzymatic tests. The study included 90 patients divided into two groups: Group 1 included 45 adults with T1DM (aged 20-40 years) exhibiting gastrointestinal symptoms of CD. Group 2 consisted of 45 asymptomatic adults with T1DM (aged 20-40 years). Celiac serology markers were positive in 3 patients (6.7%) from Group 1 and in 1 patient (2.2%) from Group 2. In Conclusion, there is a significant association between CD and T1DM. Celiac serology should be conducted in T1DM patients presenting with gastrointestinal and/or extraintestinal symptoms.
Keywords:
Celiac disease, Type 1 diabetes mellitus (T1DM), Silent, Serology, Endoscopy.
Date received:
13 December 2024; accepted: 11 May 2025
PMID:
40682774
Full Text