Assessment of Herpes virus infection and Cytomegalovirus infection and their relation to multiple sclerosis … Original Research Article … |
The Egyptian Journal of Immunology E-ISSN (2090-2506) Volume 32 (2), April 2025 Pages: 27–34. www.Ejimmunology.org https://doi.org/10.55133/eji.320203 |
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| Mona Salama1, Mohamed El-Samahy2, Maha M. Anani3, Fadia Attia3, Shaimaa A. A. M. Amer4, Shereen H. Ahmed5, Eman S. Albeltagy6, Abdallah A. Hammour7,8, and Rania M. Saleh3 |
| 1Department of Clinical Pathology, Faculty of Medicine, Port Said University, Egypt.
2Department of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. 3Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. 4Department of Public Health, Occupational & Environmental Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. 5Department of Medical Microbiology & Immunology, Faculty of Medicine, Benha University, Benha-Egypt. 6Department of Internal Medicine, Faculty of Medicine (For Girls), Al-Azhar University, Cairo, Egypt. 7Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, (For boys), Cairo, Egypt. 8Department of Ophthalmology, Abha Private Hospital, Abha, Saudia Arabia.
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Corresponding author: Maha M. Anani, Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Email: mahaenany77@gmail.com |
Abstract
Numerous studies examined the connection between viral infections and the onset and progression of multiple sclerosis (MS). Herpes simplex virus type 1 (HSV1) was linked to MS. Additionally, research showed that people with MS tend to have higher levels of antibodies against cytomegalovirus (CMV) compared to those without MS. Some studies suggested that CMV infection may result in a more severe form of MS. There is still an ongoing debate regarding the direct role of HSV1 and CMV in MS. Therefore, our objective was to investigate the potential links between HSV1, CMV infections, and MS. This case-control study included 22 MS patients attending the Neurology Clinic at Suez Canal University Hospital, Ismailia, Egypt, and 22 normal controls matched for age and gender. CMV-specific IgM and IgG levels and HSV-specific IgM and IgG levels were measured using an automated analyzer. There was no statistically significant difference in IgM and IgG antibody titers to HSV or CMV between MS cases and controls. The study found no correlation between CMV IgG, IgM, or HSV IgG, IgM, and MS severity. In conclusion, there was not enough data to establish a link between HSV infections and MS severity.
Keywords:
MS, CMV specific IgM and IgG, HSV specific IgM and IgG levels, Expanded Disability Status Scale.
Date received:
09 May 2024; accepted: 20 February 2025
PMID:
40272919
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