Physiology and immunology of the adrenergic anti-inflammatory pathway … Original Research Article …

The Egyptian Journal of Immunology
E-ISSN (2090-2506)
Volume 31 (4), October 2024
Pages: 46–57.
www.Ejimmunology.org
https://doi.org/10.55133/eji.310405
Alaa A. Aboulata1,2, and Ibrahim M. Shatla3,4
1Department of Biomedical & Dental sciences, Faculty of Dentistry, Al-Baha University, Saudi Arabia,

2Department of Medical Microbiology and Immunology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

3Department of Physiology, Faculty of Medicine, Al-Baha University, Saudi Arabia.

4Department of Physiology, Demietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.

Corresponding author:
Alaa A. Aboulata, Department of Biomedical & Dental sciences, Faculty of Dentistry, Al-Baha University, Saudi Arabia.
Email: aaalansari@bu.edu.sa.

 

Abstract

The adrenergic anti-inflammatory pathway represents a critical intersection between the nervous and immune systems, modulating the body’s response to inflammation through the action of catecholamines on adrenergic receptors. This review explored the physiology underlying this pathway, focusing on the mechanisms by which the sympathetic nervous system influences immune function. We delved into the roles of specific adrenergic receptors, primarily the beta-adrenergic receptors, in mediating anti-inflammatory effects, highlighting the involved molecular signaling pathways. Additionally, we examined the immunological implications of adrenergic modulation, discussing how these pathways contributed to the resolution of inflammation and the potential for dysregulation in various disease states. Emerging evidence on the therapeutic potential of targeting the adrenergic anti-inflammatory pathway in conditions such as sepsis, autoimmune diseases, and chronic inflammatory disorders was also reviewed. By integrating current knowledge on the physiology and immunology of this pathway, this review aimed to provide a comprehensive understanding of its role in health and disease, offering insights into future research directions and clinical applications.

Keywords:
Adrenergic Receptors, anti-inflammatory pathway, catecholamines, Immune Responses.

Date received: 03 June 2024; accepted: 27 August 2024

PMID:
39417740

 

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