Assessment of the impact of cytomegalovirus seropositivity on blood parameters in renal hemodialysis patients….. Original Research Article….. |
The Egyptian Journal of Immunology E-ISSN (2090-2506) Volume 31 (3), July, 2024 Pages: 113–122. www.Ejimmunology.org https://doi.org/10.55133/eji.310311 |
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Rasha Emad1, Wallaa Y. Badr-Aldin2, Maha Anani3, Yara E. Marei4, Mohammed G. Sakr5, and Gehan A. Ibrahim3 |
1Department of Clinical Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt.
2Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. 3Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. 4Department of Medical Microbiology & Immunology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. 5Department of Tropical Medicine & Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. |
Corresponding author: Rasha Emad, Department of Clinical Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt. Email: dr.rashaemad@hotmail.com |
Abstract
End-stage renal disease (ESRD) patients are considered immunocompromised, putting them at high risk for infections, including cytomegalovirus (CMV). CMV can affect hematological parameters, causing further complications in ESRD patients. This study intended to determine the seropositivity of CMV infection in hemodialysis patients and its effect on different blood parameters in ESRD patients to help decrease the overall dialysis associated morbidity and mortality. Blood samples were collected from 45 ESRD patients and 45 controls. A complete blood count was performed using an automated cell counter. CMV-specific IgM and IgG levels were measured using immunochemistry testing. The seropositivity for CMV-IgG was 42.2% in ESRD patients which was significantly higher than in control group (22.2%) (p=0.042). The seropositivity for CMV-IgM was 6.7% in ESRD patients with no difference with the control group (4.4%). The prevalence of anemia was significantly higher in CMV seropositive (77.3%) compared to CMV seronegative (47.8%) ESRD patients. Other studied blood parameters were not different between CMV seronegative and seropositive ESRD patients. In conclusion, CMV infection is a significant concern for dialysis patients and can affect hematological parameters, leading to further complications. Early detection and treatment of CMV infection and monitoring of CMV IgM and IgG levels are critical to prevent further complications and improve clinical outcomes.
Keywords:
Hemodialysis; Cytomegalovirus; Anemia
Date received:23 October 2023; accepted: 22 June 024
PMID:
38995716
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