Impact of Toll-like receptor 2 (rs5743708) gene polymorphism in pediatric pneumonia: risk and severity….. Original Research Article….. |
The Egyptian Journal of Immunology E-ISSN (2090-2506) Volume 31 (3), July, 2024 Pages: 48–55. www.Ejimmunology.org https://doi.org/10.55133/eji.310305 |
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| Samar M. Abd El-Hamid1, Alshaymaa A. Abd Elalim1, Eatemad N. A. Mansour2, Shimaa Moustafa2, Eman M. Moazen3, Walaa H. Abdo4, Amal K. A. Abou Elnour4 and Asmaa A. Elsheikh5 |
| 1Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
2Department of Pediatrics, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. 3Department of Chest disease, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. 4Department of Radio-diagnosis, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. 5Department of Community & Occupational Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. |
Corresponding author: Samar M. Abd El-Hamid, Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. Email: drsamar33@yahoo.com. |
Abstract
Pediatric pneumonia is a common respiratory infection that affects children and is thought to be a major source of mortality and morbidity worldwide, particularly in low- and middle-income nations. Toll-like receptor2 (TLR2) is an important receptor involved in the recognition of bacterial pathogens and the activation of the immune response. Genetic variability in TLR2 may partially explain individual differences in susceptibility to infections. The purpose of this study was to investigate the possible contribution of the TLR2 (rs5743708) variant to the risk and severity of pediatric pneumonia infection. The study included 100 pediatric patients diagnosed with pneumonia and 100 normal controls who were age and gender matched. Real-time polymerase chain reaction (PCR) was used to genotype participants for the TLR2 (rs5743708) variant. The analysis revealed that children with the TLR2 (rs5743708) (G/A) genotype showed a 2.52-fold greater risk of having pneumonia (OR: 2.52; 95% CI: 1.32-4.79; p = 0.005) in comparison with patients who have wild homozygous genotypes. Furthermore, we observed that the TLR2 (rs5743708) (A) allele is connected to a greater risk of pneumonia infection in children (OR: 1.612; 95% CI: 1.07-2.43; p = 0.023) but did not significantly influence infection severity. In conclusion, children with the TLR2 (rs5743708) mutant (G/A) genotype and (A) allele had a significantly higher risk of having pneumonia, but they were not at high risk for the severity of the infection.
Keywords:
Pneumonia, Toll-like receptors2, Pediatric Respiratory Severity Score, polymorphism.
Date received:22 October 2023; accepted: 23 May 2024
PMID:
38990062
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