Association between estrogen receptor alpha and aryl hydrocarbon receptor gene polymorphisms in the prognosis of breast cancer in Egypt |
The Egyptian Journal of Immunology Volume 31 (2), April, 2024 Pages: 87 – 92. www.Ejimmunology.org https://doi.org/10.55133/eji.310209 |
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| Sara A. Aboelroos1, Elsayed H. M. Eltamany2, Faten A. M. Mohamed3, and Marwa A. Suliman4 |
| 1Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
2Department of Organic Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt. 3Department of Biochemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt. 4Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. |
Corresponding author: Faten A. M. Mohamed, Department of Biochemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt. Email: fatenabdulmonem@science.suez.edu.eg |
Abstract
Breast cancer is the most malignant tumor among women in the world. Single nucleotide polymorphisms (SNPs) might better predict breast cancer prognosis. PvuII (T/C substitution), XbaI (A/G substitution), and aryl hydrocarbon (AhR) (G/A substitution) were evaluated as possible genetic prognostic factors for breast cancer. The aim of the current study was to assess the relation between PvuII (rs2234693), XbaI (rs9340799), and aryl hydrocarbon receptor gene polymorphisms AhR (rs2066853) in breast cancer prognosis. This was a case-control study that included 120 breast cancer patients classified into two groups. The first group included 60 patients with good prognostic factors, and the second group included 60 patients with poor prognostic factors. Blood samples were taken from all study participants to perform the genotyping assay. We found that positive genotypes of PvuII, XbaI, and AhR polymorphisms were strongly associated with better prognostic factors for breast cancer patients, while negative genotypes of PvuII and XbaI were more and significantly prevalent in poor prognostic breast cancer patients. We conclude that PvuII T/C, XbaI G/A, and AhR G/A alleles may be prognostic for breast cancer progression.
Keywords:
breast cancer, aryl hydrocarbon receptor, Xbal, PvuII and prognostic factors
Date received:
11 June 2023; accepted: 14 March 2024
PMID:
38615265
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