Impact of serum IL 10 on prediction of early allograft rejection in liver transplantation |
The Egyptian Journal of Immunology Volume 31 (1), January, 2024 Pages: 162 – 173. www.Ejimmunology.org https://doi.org/10.55133/eji.310117 |
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Mai A. El-Deeb1, Ashraf Okba1, Mahmoud EL-Meteini3, Eman E. Ahmed1, Rasha S. Mohamed2, Rasha Mamdouh4, and Mariam Maged1 |
1Department of Internal Medicine, Allergy & Immunology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2Department of Internal Medicine, Gastroenterology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 3Department of General Surgery, Hepato-Pancreato-Biliary & Liver Transplant Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 4Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. |
Corresponding author: Rasha S. Mohamed, Department of Internal Medicine, Gastroenterology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Email: rasha.samir@med.asu.edu.eg |
Abstract
Tissue transplantation is the preferred treatment for end organ failure such as heart, lung, kidney, and liver. The immune system recognizes the transplant as non self if the donor and recipient are not genetically identical. Multiple cytokines are involved in this process; however, little is known about their predictive role in rejection. Interleukin 10 (IL-10) which exhibits anti-inflammatory activity could be used as early predictor of acute rejection. The current study intended to determine any potential relationship between acute allograft rejection and blood IL-10 levels in liver transplant (LT) recipients. This study included 45 patients with cirrhotic liver diseases planned for transplantation. Patients were followed up for 2 months and then divided into two groups: patients who developed early acute rejection and those who did not develop rejection (as controls). Of the study patients, 38 (84.4%) patients did not develop rejection and 7 (15.6%) patients developed rejection. The levels of IL-10 did not change during rejection of the LT. In conclusion, the findings of the current study indicated no relation of IL-10 levels during LT rejection.
Keywords: breast cancer, HPV, Treg
Date received: 25 May 2023; accepted: 12 December 2023
PMID:
38225775
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