NLRP3 inflammasome (rs10754558) gene polymorphism in patients with atopic dermatitis |
The Egyptian Journal of Immunology Volume 30 (3), July, 2023 Pages: 102 – 109. www.Ejimmunology.org https://doi.org/10.55133/eji.300311 |
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| Aya El Gendy1, Fawzia H. Abo Ali1, Shereen A. Baioumy2, Sara I. Taha3, Mahy El-Bassiouny4, and Osama M. Abdel Latif1 |
| 1Department of Internal Medicine, Allergy & Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2Department of Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. 3Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 4Department of Dermatology, Andrology & Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. |
Corresponding author: Sara I. Taha, Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Email: dr_sara_ib@med.asu.edu.eg. |
Abstract
The nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome is a high molecular weight protein complex that has been linked to a variety of allergic and inflammatory disorders in humans, including atopic dermatitis (AD). Polymorphisms in NLRP3 genes could lead to immune dysregulation. This case-control study aimed to assess the association between NLRP3 inflammasome (rs10754558) gene polymorphism in AD and the incidence and severity of the disease. We included 62 subjects in each of the AD and control groups. Serum total IgE levels and NLRP3 inflammasome (rs10754558) gene polymorphism were assessed and compared between the two study groups and among the AD group as arranged by disease severity. The AD group showed significantly higher levels of serum total IgE compared to controls (p˂0.001). Serum IgE levels were also significantly associated with AD severity. The (rs10754558) G allele was significantly predominant among AD participants (OR: 2.33; 95% CI: 1.1 -4.92) and 51.6% of the AD group was carriers of the GG genotype. Moreover, there was a substantial correlation between NLRP3 (rs10754558) G allele and AD score index for disease severity (OR: 7.17; 95% CI: 1.47 – 35.7). In conclusion, NLRP3 inflammasome (rs10754558) gene polymorphism G allele could be an important factor in the predisposition and exacerbation of AD.
Keywords:
Allergy, Atopic dermatitis, Gene polymorphism, Inflammasome, NLRP3.
Date received:
21 January 2023; accepted: 07 June 2023
PMID:
37440332
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