The role of cytokine gene single nucleotide polymorphism in the development of recurrent acute otitis media

The Egyptian Journal of Immunology
Volume 29 (1), January, 2022
Pages: 13–18.
www.Ejimmunology.org
https://doi.org/10.55133/eji.290102
Mohammed A. Fouad1,4, Effat H. Assar2, and Yasser A. Fouad3
1Medical Microbiology & Immunology Department, Faculty of Medicine, Benha University, Benha, Egypt.

2Pediatric Department, Faculty of Medicine, Benha University, Benha, Egypt.

3Otorhinolaryngology-Head & Neck Surgery Department, Faculty of Medicine, Zagazig University, Egypt.

4Public Health Department, Health Sciences College at Al-Leith, Umm Al-Qura University, KSA.

Corresponding author: Mohammed A. Fouad, Medical Microbiology & Immunology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Email:
mohamed.alsayed01@fmed.bu.edu.eg.

Abstract

The study aimed at examining the role of single nucleotide polymorphism (SNP) of cytokine genes in the development of recurrent acute otitis media (AOM) among children. Single nucleotide polymorphism of IFN-g, IL-6, IL-10, TNF-α, and TGF-β1, were analyzed by the polymerase chain reaction with sequence-specific primers (PCR-SSP) in 82 children with recurrent AOM and compared with a similar control group. There was a significant higher incidence of IL-10 polymorphisms (loci -592, -819 and -1082) in children with recurrent AOM (P=0.0137, 0.0137 and 0.0072, respectively). However, there was no significant difference in the distribution of other cytokine genotypes between the two study groups. Among the 5 studied cytokine genes, only IL-10 loci showed significant correlation to the development of recurrent AOM.

Keywords: Cytokines; Gene polymorphism; Otitis media

Date received: 22 November2021; accepted: 22 December 2021

PMID: 35171543

 

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