Krebs von den Lungen‐6, a promising marker in evaluating the severity of interstitial lung disease in Egyptian rheumatoid arthritis patients

The Egyptian Journal of Immunology
Volume 28 (4) ,October , 2021
Pages: 241–249.
www.Ejimmunology.org
https://doi.org/10.55133/eji.280425
Rasha M. Hammoda1, Haitham Salah-ElDin2, Nermin H. EL-Gharbawy 3 and Dina Ragab4
1Department of Internal Medicine & Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

2Department of Chest, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

3Department of Physical Medicine, Rheumatology & Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

4Department of Clinical pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

 

Corresponding author: Dina Ragab, MD, Department of Clinical pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Email: dinaragab@med.asu.edu.eg.

Abstract

Krebs von den Lungen-6 (KL-6) is one of the mucins associated with interstitial lung disease. We aimed to assess the value of KL-6 as a marker for detecting the presence of interstitial lung disease in Egyptian rheumatoid arthritis patients and to evaluate its ability to assess severity in different grades of interstitial lung disease. The study included 89 rheumatoid arthritis patients; 64 patients with interstitial lung disease and 25 patients without interstitial lung disease. Serum levels of KL-6 were assessed using enzyme linked immunosorbent assay. Levels of KL-6 were higher in patients with interstitial lung disease compared to patients without interstitial lung disease (P< 0.001). KL-6 levels were significantly higher in grade 4 patients than those in grades 1 and 2. Also, KL-6 levels were significantly higher in grade 3 patients than those in grades 1 and 2. Kl-6 levels were also higher in grade 2 patients compared to grade 1 patients. Finally, no difference was observed between grade 4 patients and grade 3 patients. KL-6 levels were significantly higher in usual interstitial pneumonia pattern compared other patterns (P=0.015). In conclusion, KL-6 is a potential circulating biomarker that may have a substantial role in detecting the presence and evaluating the severity of interstitial lung disease among rheumatoid arthritis patients.

Keywords: interstitial lung disease; Krebs von den Lungen-6; rheumatoid arthritis.

Date received: 23 August 2021; accepted: 27 September 2021

PMID: 34882373

 

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