Vitamin D receptor gene polymorphism and its relation to cancer colon occurrence

The Egyptian Journal of Immunology
Volume 30 (2), April, 2023
Pages: 174 – 180.
Mohamed G. Soliman, Wafaa Omar, Nader Nemr, Adel A. Hassan, and Ahmed Gaber
1Department of Endemic & Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.


Corresponding author: Wafaa Omar, Department of Endemic & Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.



Cancer colon is the second most prevalent cancer for females and the third for males. Vitamin D’s cellular impacts are achieved by 1,25 (OH) 2D binding to the Vitamin D receptor (VDR). This study aimed at assessing the relation between vitamin D receptor gene polymorphism and cancer colon. This case-control study included 50 colorectal cancer (CRC) cases which were candidates for colonoscopy and 50 controls with normal colonoscopy. The study was conducted in Suez Canal University hospitals. All cases were diagnosed with colonoscopy and confirmed with histopathology. Blood samples from study subjects were used for detection of vitamin D receptor FokI polymorphism. We found that more than two thirds of patients were males. Around half of the cases were over 60 years old. Most of the study participants were overweight (26%), obese (53%), non-alcoholics (99%), and non-smokers (72%). However, about one third of the patients were diabetic (31%). Noticeably, none of these factors was significantly variant among CRC group and normal colonoscopy group (p< 0.05). The most common presentation among cases with colon cancer was constipation (80%). Of the 100 studied cases, 74% had left-sided colon cancer, with a 66% of them were resectable. The odds ratio of VDR polymorphism between the cases and control groups was high (3 with 95% CI (0.3-31)), however it did not reach statistical significance (p= 0.3). Most of the cases with VDR polymorphism had colon cancer (75%). In conclusion, based on our findings, there was no correlation between colorectal cancer and vitamin D receptor gene polymorphism.

Cancer Colon, Vitamin D, Gene Polymorphism

Date received:
20 November 2022; accepted: 24 January 2023.



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